haha this is where i come in ...
My missus has an apartment over there , and we go over a few times a year ...
I love the place , fist few days you should deffo do the tourist Prague thing , go see all the spots , the bridge , castle , the tower thing on the hill , the jewish quarter ,
Then if the missus is with you hit the palladium for some shopping , and some serious perving , then get on the underground to letnany , one of the other out of town shopping centres , just remember "priste stanice" means "next station" when you hear it on the loudspeaker .
as for boozing , ya gotta see coyote in old town, just like coyote ugly with young wans jumping up on the bar every few minutes ... some talent in there ,the ubiquitous irish bars , and numerous other places will serve ya decent beer for fock all .
For a bit of dancing later you could try the big place The ROXY, with 5 floors, but its a bit hardcore , get in a taxi and go to radozt . Its owned by a jamaican ,Rico is his name ,good friend of the womans , big hop hop club ... rihanna video for please dont stop the music was shot there .
Oh and deffo go have a look at the prestige car shop on revolucni street .. Its the street with the trams on it outside the palladium shopping centre , follow it down to the river , and its on your left ... All the finest japanese and americana you can find , from GTR's, camaros , to hummers . On that street youll also find some brilliant skate and surf shops , (revolution is the name of one , ) and a very good interior design place for the lady , they sell lots of funky gadgets for around the home .
and most of all have fun